Detection of Subclinical Anthracyclines' Cardiotoxicity in Children with Solid Tumor

• DOI: 10.4103/0366-6999.233950
• Publication Date: 2018-06-08T05:09:23Z
• Authors: Hui-Min Hu; Xiao-Lin Zhang; Wei-Ling Zhang; Dong-Sheng Huang; Zhong-Dong Du
• Keywords: Cardiotoxicity; Subclinical infection; Cumulative dose

Background: Cardiotoxicity is one of the most serious chronic complications anthracyclines therapy. Assessment left ventricular ejection fraction (LVEF) fails to detect subtle cardiac dysfunction (LV). This study aimed and evaluate new parameters subclinical anthracyclines' cardiotoxicity in children with solid tumor. Methods: A detailed echocardiographic examination was performed 36 hepatoblastoma or rhabdomyosarcoma after receiving chemotherapy healthy controls from January 2015 December 2016. The LVEF, ratio early diastolic peak velocity transmitral flow (E) septal e' mitral annular (e'), tricuspid plane systolic excursion (TAPSE), LV global longitudinal strain (GLS) were evaluated using M-mode, tissue Doppler imaging (TDI), two-dimensional speckle tracking echocardiography (2D-STE), respectively. Echocardiographic compared between patient group controls. All patients divided into two subgroups based on their cumulative dosage (<300 mg/m2 subgroup ≥300 subgroup). Results: had no presentation heart failure LVEF within normal range (65.7 ± 5.1%). Compared controls, mean E/e' increased significantly (7.9 0.7 vs. 10.2 3.5, t = 3.72, P < 0.01), TAPSE decreased (17.2 1.3 mm 14.2 3.0 mm, −4.03, GLS (−22.2% 1.9% −17.9% 2.9%, -5.58, 0.01) group. 300 mg/m2, (−18.7 2.7% −16.5 2.1%, 2.15, 0.04), (9.1 1.5 11.5 4.9, −2.17, (14.2 2.1 12.5 2.2 −2.82, 0.02) mg/m2. Conclusions: helpful detection 2D-STE. are other sensitive detecting both ventricles by TDI. These show significant change different dosage, so should be controlled clinical treatment.