Expression of CDX-2 and Ki-67 in different grades of colorectal adenocarcinomas

• DOI: 10.4103/0377-4929.155304
• Publication Date: 2015-04-17T03:04:35Z
• Authors: RamNarayan Das; Shatavisha Dasgupta; Uttara Chatterjee; Chhanda Datta; BitanK Chattopadhyay; Anway Sen; Sumit Mitra; Koushik Saha; Krishnendu Mukherjee
• Keywords: CDX2; Ki-67; Immunostaining; Grading (engineering)

CDX2 is a caudal homeobox gene essential for intestinal differentiation and specifically expressed in colorectal adenocarcinomas. Its role carcinogenesis not fully elucidated.To study the expression pattern of Ki-67 different grades adenocarcinomas to observe relationship their staining patterns various tumor stages look correlation if any, between labeling index (Ki-67 LI) expression.A total 74 cases were enrolled. Detailed clinical profile, peroperative findings, histological grading staging noted. Immunohistochemistry was done, LI calculated. graded semi-quantitatively, statistical analysis done.Age presentation ranged from 20 75 years, male:female ratio 1.83:1. There 8, 47 13 well, moderate poorly differentiated adenocarcinomas, respectively. The mean 14.25, 31.34 43.08 respectively, difference statistically significant, also noted with stage. appeared be stronger cases, but there no significant its stages. immunostaining pattern. lymph node metastasis showed positivity all cases.Expression does significantly change grade However, it an important diagnostic marker metastatic colonic lesions. LI, on other hand, strong histopathological grades.