In vitro and In vivo antioxidant activity of flavonoid extracted from mulberry fruit (Morus alba L.)

• DOI: 10.4103/0973-1296.177910
• Publication Date: 2016-03-02T13:05:55Z
• Authors: Zhongzheng Gui; SivakumarThasma R...; Ajay KrishnaPalan...; Cheng Chen; Chao Jin; Shao-Hui Li; Hui-Juan Chen
• Keywords: 0301 basic medicine; 03 medical and health sciences; Original Article; 3. Good health

Pharmacognosy Magazine,2016,12,46,128-133.DOI:10.4103/0973-1296.177910Published:March 2016Type:Original ArticleAuthors:Sivakumar Thasma Raman, jay Krishna Palani Gounder Ganeshan, Cheng Chen, Chao Jin, Shao-Hui Li, Hui-Juan and Zhongzheng Gui Author(s) affiliations:Sivakumar Ajay School of Biotechnology, Jiangsu University Science Technology, Zhenjiang 212018, Province, P.R. China Abstract:Background: Many plants possess antioxidants that exhibit additive or synergistic activities. Objective: In this study, an ethanol-extracted flavonoid extracted from mulberry fruit (FEM) was evaluated for the antioxidant activity in vitro hemolysis red blood cell (RBC) lipid peroxidation liver vivo. Materials Methods: Antioxidant activities were measured by quantifying its 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, reducing power, Fe2+-chelating ability. FEM inhibits RBCs effects estimated. Results: The total content compounds 187.23 mg quercetin equivalents per grams dried material. assays, demonstrated a strong effect, especially DPPH power. Mouse RBC induced H2O2was significantly inhibited dose- time-dependent manner. on liver, mitochondria, microsome investigated. percentage inhibition at high concentration (100 μg/mL) 45.51%, 39.36%, 42.78% microsomes, respectively. These results suggest possesses both vivo vitro. Keywords:antioxidant Flavonoid, hemolysis, Lipid peroxidation, fruitView:PDF (1.18 MB) Full Text