Turmeric use is associated with reduced goitrogenesis: Thyroid disorder prevalence in Pakistan (THYPAK) study

• DOI: 10.4103/2230-8210.152768
• Publication Date: 2015-03-05T09:08:49Z
• Authors: Ali Jawa; Ali Jawad; SyedHunain Riaz; Muhammad ZamanKha...; AbdulWahid Chaudhary; Muhammad Zakria; Javed Akram
• Keywords: Thyroid Nodules

South Asian population has a particularly high prevalence of thyroid disorders mainly due to iodine deficiency and goitrogen use. There is no data available for in the general living nonmountainous regions Pakistan.A total 2335 residents Pak Pattan, Punjab, Pakistan were interviewed about demographic, dietary, medical environmental history as well screened goiter. Individuals all ages either gender included.Median age was 34 (10-88) years 1164 (49.9%) males. Median monthly income 49 (3.9-137) USD. Six hundred sixty-nine (28.7%) subjects had palpable 77.5% (n = 462) 22.5% 133) World Health Organization Grade I II goiters respectively, further by measuring thyroid-stimulating hormone (TSH). In with TSH <0.4 mg/dL, free T3 T4 levels measured. 185 goiter when measured, 50% 93) euthyroid, 48% 89) hyperthyroid, one subject each hypothyroid subclinically hyperthyroid. 29/89 hyperthyroid underwent radionuclide scanning. Twelve heterogeneous uptake consistent multinodular goiter, 12 diffuse uptake, two cold nodules hyperfunctioning single nodules. Goiter significantly more common among females, unmarried individuals drinking tube (subterranean) water. less those who consumed daily milk, ghee (hydrogenated oil), spices, chilies, turmeric.In our study population, endemic very hyperthyroidism. Turmeric use association reduced goitrogenesis. Further studies assess sufficiency, thiocyanate exposure autoimmunity need be conducted. Masses consuming diets should educated incorporate turmeric, spices green chilies their cooking recipes, reduce risk development. addition, iodized salt diet cannot overemphasized.