The Comparison of Preventive Analgesic Effects of Ketamine, Paracetamol and Magnesium Sulfate on Postoperative Pain Control in Patients Undergoing Lower Limb Surgery: A Randomized Clinical Trial

• DOI: 10.4103/2277-9175.217217
• Publication Date: 2017-10-25T07:21:29Z
• Authors: Shahpour Pourali; SeyedMorteza Heydari; SeyedJalal Hashemi
• Keywords: Pain control

Background: In considering the importance of postoperative pain management and its consequences on related secondary outcomes including nausea, vomiting, operation-related complications, we aimed to compare effectiveness three analgesic agents ketamine, paracetamol, magnesium sulfate for relief associated in this trial. Materials Methods: double-blinded randomized control clinical trial, patients scheduled elective lower extremity orthopedic surgery under general anesthesia were enrolled into four groups receiving intravenous ketamine (0.25 mg/kg), paracetamol (15 (7.5 placebo (normal saline), immediately after induction anesthesia. Postoperative scores, analgesic, metoclopramide use, frequency vomiting satisfaction score studied during 6 h, 6–12 12–24 h recovery recorded compared. Results: thirty each groups. Mean was significantly group than others 24 (P < 0.001). additive use 12 0.001), but it not different = 0.12). between > 0.05). Excellent good higher other 0.04). Conclusions: Ketamine has more superior effect controlling sulfate.