Prevalence and Risk Factors of Peripheral Neuropathy in Parkinson's Disease

• DOI: 10.4103/aian.aian_669_22
• Publication Date: 2022-11-19T08:48:58Z
• Authors: Aparna Ramachandran; James Jose; Abdul V Gafoor; Smita Das; Neetha Balaram
• Keywords: peripheral neuropathy; small fiber neuropathy; 3. Good health; 03 medical and health sciences; neurodegenerative disease; 0302 clinical medicine; parkinson's disease; Original Article; Neurology. Diseases of the nervous system; levodopa; RC346-429; large fiber neuropathy

A lesser studied aspect of Parkinson's disease (PD) is its associated peripheral sensory-motor neuropathy. Peripheral neuropathy an intriguing PD, a problem not given sufficient attention and which if tackled properly could make difference to the multifaceted sufferings PD patient. Studies regarding prevalence risk factors in patients with are scarce from Indian subcontinent.This prospective observational study was conducted tertiary care teaching hospital South India. Patients diagnosed idiopathic (IPD) were screened enrolled. All underwent detailed evaluation symptoms, signs, electrophysiology (Nerve conduction study, Sympathetic skin response), stimulated wrinkling Eutectic Mixture Local Anesthetics. found have large/small fiber additional tests exclude other causes neuropathy.A total 154 IPD enrolled (mean age: 61.96 ± 9.15 years, mean duration 4.08 3.16 years). The Hoehn Yahr (H Y) score 2.3 0.825 Unified Parkinsons Disease Rating Scale (UPDRS)-3 ON state 23.07 11.14. cumulative levodopa dose 482.68 651.76 (median: 292; range: 4728.57) grams. 49 (31.8%), large 28 (18.2%) small 47 (30.5%); overlap seen 26 (16.9%). Around 34% had serum homocysteine levels >20 mg/dl. In univariate analysis, disease, dose, level, H Y score, UPDRS-3 Toronto Clinical Neuropathy Score (P < 0.001 for all), age at presentation, rigidity predominant presentation = 0.02 both) these variables also presence 0.004 P rest), except type presentation. However, multivariate logistic regression only neuropathy.In our cohort, majority early-stage around one-fifth one-third suffer polyneuropathy, respectively. Large mainly score.