Exploring therapeutic plasma exchange as a progressive treatment modality for neurological disorders: Insights from a tertiary care hospital in Northwestern India over 3 years

• DOI: 10.4103/ajts.ajts_136_23
• Publication Date: 2024-08-30T14:36:11Z
• Authors: Anshika Yadav; Smriti Sharma; Gajendra Nath Gupta
• Keywords: Therapeutic plasma exchange; Tertiary care; Modality (human–computer interaction); Treatment modality

Abstract: BACKGROUND: Neurological disorders with autoimmune or inflammatory etiology pose significant challenges in terms of treatment. Therapeutic plasma exchange (TPE) has emerged as a promising adjunctive therapy for managing these conditions by removing pathogenic autoantibodies, immune complexes, and proinflammatory mediators. However, the experience TPE neurological northwestern part India is limited. METHODOLOGY: This retrospective study analyzed medical records patients who underwent over 3-year period at tertiary care hospital. Patient demographics, clinical diagnoses, protocols, adverse events were collected analyzed. Descriptive statistics used to summarize data. RESULTS: A total 26 (14 males, 11 females) 111 procedures during period. The most common diagnoses generalized dystonia, Guillain–Barré syndrome, myasthenia gravis, chronic demyelinating polyneuropathy. protocols involved exchanging one volume every alternate day, replacement solutions including fresh-frozen (FFP), albumin, combination FFP albumin. majority showed positive improvement measures, indicating efficacy halting disease progression ameliorating symptoms. Adverse reported seven but successfully managed. CONCLUSION: demonstrates effectiveness safety management India. measures favorable profile. These findings contribute growing recognition an emerging therapeutic modality field neurology. Further research prospective studies are needed optimize TPE’s use, patient selection, treatment long-term outcomes this population.