Ifosfamide-induced extrapyramidal neurotoxicity with COVID-19

• DOI: 10.4103/aomd.aomd_24_22
• Publication Date: 2024-05-16T18:01:24Z
• Authors: Chitrakshi Nagpal; Ayush Agarwal; Vineeta Venkatesw...; Kapil D Soni; M V Padma Srivastava; Anjan Trikha
• Keywords: Neurotoxicity

Abstract Ifosfamide, an analog of cyclophosphamide, is commonly used as a chemotherapeutic agent to treat sarcomas and solid tumors. However, neurotoxicity rare side effect this drug. When present, the symptoms range from confusion, agitation, delirium in mild cases mutism, visual blurring, hallucinations, seizures, stupor, even coma extreme cases. Within spectrum, extrapyramidal are extremely rare, when may not revert with drug discontinuation. Sequelae occasionally persist after discontinuation Our case illustrates occurrence ifosfamide-induced patient metastatic phyllodes tumor breast concomitant COVID-19 illness. Ifosfamide-induced clinical diagnosis exclusion requires ruling out other possible causes. The supported by temporal correlation administration, presence risk factors, improvement infusion cessation, along normal brain imaging.