Microscopic assessments of the effect of phoenix dactylifera L. in a rat model of mercury-triggered cerebral M1 changes

• DOI: 10.4103/atp.atp_3_21
• Publication Date: 2022-02-24T07:26:10Z
• Authors: AbelNosereme Agbon; HelenOchuko Kwana...; WilsonOliver Hamman; AustinOseloka Ibegbu; Hamisu Sule; MurtalaHamza Yahaya; Rachael Henry; AndrewEkpenyong I...
• Keywords: Chromatolysis; Neurotoxicity; Mercury

Context: Mercury is a widespread environmental and industrial pollutant that exerts toxic effects on vital organs. The cerebrum, composed of cortical areas such as the primary motor cortex (M1), vulnerable target mercury toxicity within central nervous system. Phoenix dactylifera used in folk medicine to treat diverse disorders, loss consciousness, memory disturbances, disorders. Aim: This study microscopically evaluated neuroprotective effect aqueous fruit pulp extract P. (AFPD) mercury-triggered M1 changes Wistar rats. Materials Methods: Twenty-four rats were divided into six groups (I–VI; n = 4). Group I was administered distilled water (2 ml/kg); II mercuric chloride (MCL, 5 mg/kg); III Vitamin C (100 mg/kg) + MCL (5 Groups IV, V, VI AFPD (250 mg/kg, 500 1000 respectively) followed by mg/kg). Neuroprotective property microscopic assessment region applying histological techniques analysis histometric features neurons. Statistical Analysis Used: One-way ANOVA paired sample t-test used. Results: Microscopic examination MCL-treated cerebral sections revealed histoarchitectural distortion neurodegenerative pyknosis, neuronal shrinkage, chromatolysis, pyramidal neurites, altered Nissl substance reactivity, relative control. Administration remarkably ameliorated MCL-triggered changes, especially at dose mg/kg with comparable reference drug, C. Conclusion: potentially efficacious ameliorating alterations could be attributed antioxidant properties constituent phytochemicals.