Brain-derived neurotrophic factor levels in acute stroke and its clinical implications

• DOI: 10.4103/bc.bc_23_20
• Publication Date: 2020-09-30T08:56:52Z
• Authors: Poonam Chaturvedi; AjaiKumar Singh; Vandana Tiwari; AnupKumar Thacker
• Keywords: Stroke; Acute stroke

BACKGROUND: Brain-derived neurotrophic factor (BDNF) has a very important role in repairing intact and injured brain, also known as neuroplasticity. Risk factors may affect neuroplasticity.OBJECTIVES: In this study, our aim was to delineate the levels of BDNF acute stroke with different etiology impact risk on its levels.METHODS: prospective 208 patients first-ever stroke, between 18 75 years, were included. All individuals assessed for severity type factors, association outcome stroke.RESULTS: The mean age study 55.29 ± 11.6 years. Compared healthy controls, significant decline observed after (P < 0.01). Patients National Institutes Health Stroke Scale (NIHSS) <6 1st day had significantly higher than those NIHSS >6 (9.8 ng/ml 3.8; P A difference comparing <55 >55 years (<55 years: 10.4 3.2; 9.8 4.5 22.97 3.8, 15.4 4.9; have negative (diabetics, = 0.001; alcoholics, 0.003; both diabetes mellitus + hypertension, 0.002; smokers, 0.001). not hypertensives nonhypertensives 0.06).CONCLUSION: level is reduced stroke. presence further affects level.