Association of Systemic Inflammatory Response Index with the cardiometabolic multimorbidity among US adults: A population-based study

• DOI: 10.4103/bc.bc_32_24
• Publication Date: 2025-03-23T00:32:00Z
• Authors: Jing Li; Songfeng Zhao; Xiaowen Zhang; Mengyan Fan; Jiaxin Wan; Rijin Lin; Feng Fan; Guo Liu; Sheng Guan; Aihua Liu
• Keywords: Association (psychology); Inflammatory response; Multimorbidity

Chronic inflammation plays an essential role in the occurrence and progression of cardiometabolic diseases (CMDs). We aim to examine association between a novel inflammatory biomarker Systemic Inflammatory Response Index (SIRI) different multimorbidity (CMM) statuses. This was cross-sectional study that includes general participants National Health Nutrition Examination Survey database from 1999 2018. SIRI calculated as neutrophil count × lymphocyte count/monocyte count. The CMDs were defined series including diabetes mellitus (DM), heart disease (HD), stroke. explored with outcomes weighted multivariable logistic regression models restricted cubic spline. diagnostic value evaluated using receiver operating characteristic (ROC) curves. A total 43,345 enrolled mean age 45.86 years. prevalence CMD CMM 17.14% 2.94%, respectively. Compared those without CMD, adjusted odds ratios (95% confidence interval) for each unit increase 1.14 (1.09-1.19) DM, 1.13 (1.07-1.19) HD, 1.11 (1.04-1.19) stroke, 1.17 (1.12-1.22) 1.16 (1.10-1.23) CMM, according regression. Elevated level independently associated increased CMM. There no interaction found subgroup analysis. According ROC analysis, had superior ability neutrophil-lymphocyte ratio, platelet-lymphocyte monocyte-lymphocyte ratio (area under curve [AUC] =0.581) (AUC = 0.633). positively coronary artery disease, suggesting could be potential noninvasive