The producing capabilities of Interferon-g and Interleukin-10 of spleen cells in primary and metastasized oral squamous cell carcinoma cells-implanted mice

• DOI: 10.4103/ctm.ctm_30_17
• Publication Date: 2018-01-23T12:16:22Z
• Authors: Masako Mizuno-Kamiya; Yasuka Azuma; Eiji Takayama; Harumi Kawaki; Toshihiro Inagaki; Eiichi Chihara; Yasunori Muramatsu; Nobuo Kondoh
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Aim: The aim of this study is to compare the immunomodulatory effects exerted by primary versus metastasized oral squamous cell carcinoma (OSCC) cells. Methods: Mouse OSCC line Sq-1979, 233 cells established from implanted Sq-1979 cells, and L lymph node tissues Sq-1979-implanted mice were subcutaneously inoculated into later abdominal area syngeneic C3H mice. producing capabilities interferon (IFN)-γ, a Th1 cytokine, interleukin (IL)-10, Th2 anti-CD3 antibody-stimulated spleen investigated in tumor bearing-mice. Results: quantity IFN-γ produced stimulated was significantly suppressed with 233, Conversely, production IL-10 elevated cell-implanted while markedly Conclusion: Our results suggest that have acquired differential functions compared original