Clinical characteristics and outcomes of severe acute respiratory infections in a resource-limited pediatric hematology oncology setting

• DOI: 10.4103/ejh.ejh_30_24
• Publication Date: 2024-12-30T16:01:51Z
• Authors: Fatma S.E. Ebeid; Sara Makkeyah; Marwa W. Tolba; Nouran Saber; Sara H.A. Agwa
• Keywords: Hematology; Pediatric Oncology

Objective To examine the spectrum of pathogens and outcome severe acute respiratory infections (SARIs) among admitted children with hematology/oncology disorders who presented SARIs in low-middle income countries. Patients methods The prospective observation study recruited 52 children, clinically assessed, their nasopharyngeal oropharyngeal swabs were examined analyzed by real-time multiplex PCR. Results 27 females 25 males, mean age 5.2 ± 2.9 years, 36 (69.2%) had pediatric malignancies, mostly (67%) hematologic eight (15.4%) chronic hemolytic anemia. Forty-eight (92.3%) fever, 42 (80.7%) a cough at time presentation. median from onset symptoms till admission was 3.0 (1–6) days, length hospital stay 9.0 days (4–16.5). Respiratory detected 39 (75%) samples, Klebsiella pneumoniae (50%), Streptococcus (30.8%), Pdm H1N1 (33.3%), rhinoviruses (25.6%). Bacterial viral codetected 19 (48.7%) cases. Five (9.6%) required ICU admission, four (7.7%) patients died during period; one failure, septic shock, two primary disease ICU. Conclusion present added more insights about bacterial agents involved SARI cases Egypt vulnerable groups.