Acetylcholine iontophoresis in diabetic patients with and without peripheral neuropathy: a potential therapeutic tool

• DOI: 10.4103/ejim.ejim_51_17
• Publication Date: 2018-09-27T05:35:26Z
• Authors: Ibrahim Ismail Ab...; Mohamed Ahmed Hus...; Gihan Samir Mousa; Amany Raafat Mohamed; Nagwa Mohamed Badr; Alaa A. Hamid
• Keywords: Iontophoresis

Iontophoresis had been widely used as a therapeutic option in the field of dermatology and physiotherapy. In vascular medicine, vasodilating response to acetylcholine (ACh) iontophoresis also previously studied evaluation endothelial dysfunction diabetes mellitus its microvascular complications but less was published about implementations. The current study aimed at investigating role ACh improvement seen diabetic patients with without peripheral neuropathy (PN). Forty type 2 mellitus, 20 PN, were subjected program three times week for successive weeks ‘long-term iontophoresis’. Percentage change perfusion measured two groups using laser Doppler flowmetry. Readings taken pretreatment post-treatment on occasions: baseline temperature, after local warming 35°C, maximal flow exposure ‘short-term Perfusion significantly improved therapy percentage 180.65 vs. 131.50% baseline, 219.45 149.40% 35°C 269.60 236.95% short-term those respectively, P values 0.0004, 0.0005, 0.049, respectively. may be an optional treatment procedure improving cutaneous diabetics further randomized control studies.