Association between preoperative frailty and postoperative delirium and cognitive dysfunction in elderly patients undergoing surgery under general anaesthesia: A prospective observational study

• DOI: 10.4103/ija.ija_872_24
• Publication Date: 2025-05-14T06:00:16Z
• Authors: K Anjaleekrishna; Dalim K. Baidya; Rohit Verma; Bikash R. Ray; Rahul K. Anand; Akhil K. Singh; Souvik Maitra; Puneet Khanna
• Keywords: Postoperative cognitive dysfunction

Advancing age is associated with poor physiological reserve to combat stressors of surgery and anaesthesia, which termed frailty, it leads postoperative complications. Frailty has been found have a strong association delirium (POD) cognitive dysfunction (POCD) in cardiac surgeries. This study aims determine the frailty POD POCD patients undergoing non-cardiac A prospective observational, cohort was done at tertiary-level hospital on 130 aged 55 years above under general anaesthesia. Preoperative classified using 5-factor modified index (5mFI) sarcopenia [hand grip strength (HGS)]. were assessed revised Delirium Rating Scale (DRS) Addenbrooke's Cognitive Examination-III 24 h, 72 h 30 days after surgery. Association between 5mFI HGS calculated linear regression model. Of 117 analysed, 58% identified as frail (5mFI score ≥0.2), exhibiting 2.9 times higher risk [odds ratio (OR) 2.933, 95% confidence interval (CI): 1.001, 8.600, P = 0.050] 5.8 (OR: 5.380, CI: 1.718, 16.685, 0.004) compared non-frail counterparts. The correlation DRS-98 scores statistically significant (P < 0.001), indicating moderate positive association. However, sarcopenic displayed but insignificant incidence rates 1.967, 0.771, 5.014, 0.157) 1.070, 0.442, 2.589, 0.880) than non-sarcopenic patients. Patients >0.4 showed notably increased adverse events within post-surgery. Our proves hypothesis that apart from age, contributes POCD. Using predictor pre-anaesthetic checkups can help identify vulnerable early implement necessary interventions decrease burden decline.