Changes in cytokine profile of M1 macrophages with administration of Swarna vachadi yoga - An observation

• DOI: 10.4103/ijar.ijar_161_24
• Publication Date: 2025-04-07T19:18:24Z
• Authors: Himanshu Rawat; Karishma Bhatia; Vikas Kumar Gupta; Sanjeev Kumar Upa...; Nisha Kumari Ojha

Background: Swarna prashana is an ancient method of administering bhasma and specified herbs in a medium ghee honey to boost immunity children. One the formulations vachadi yoga (SVY) containing bhasma, Vacha, Kushtha, Madhu (honey), Ghrita (clarified butter) widely used treat recurrent respiratory viral infections Aim: To evaluate immunomodulatory effect SVY ascertain its agreement with traditional usage. Methods: Human-derived monocytic cell line THP-1 was for this study. Upon stimulation lipopolysaccharide, these cells differentiate into M1 macrophages secrete inflammatory cytokines. Expression levels cytokines were studied upon treatment SVY. Results: The derived from resulted alteration cytokine expression level. increases Interleukin (IL)-1β tumor necrosis factor-α, suppresses IL-6 interferon gamma. also changed morphology suggestive anti-inflammatory effect. Conclusion: This study reports possible mode action reducing severity