A retrospective analysis of serological & molecular testing data on dengue fever in Kolkata & adjacent districts during 2016-2019

• DOI: 10.4103/ijmr.ijmr_2612_19
• Publication Date: 2024-04-16T07:04:33Z
• Authors: Agniva Majumdar; Rajarshi Gupta; Ananya Chatterjee; Hasina Banu; Madhumonti Biswas; Rudrak Gupta; Soumen Mukherjee; Provash Sadhukhan; Shanta Dutta
• Keywords: Dengue; Molecular Diagnostic Techniques; Immunoglobulin M; Fever; Humans; Dengue Virus; Serogroup; Programme: Original Article; Retrospective Studies

Regional Virus Research and Diagnostic Laboratory established at ICMR-National Institute of Cholera Enteric Diseases (NICED) regularly receives samples for dengue screening serotyping from patients acute febrile illness (AFI) Kolkata adjacent districts. In this study, data over a three year period (August 2016-July 2019) was retrospectively analyzed to provide insight into the epidemiological trends fever in region.Serological performed by detection NS1 antigen and/or immunoglobulin M (IgM) antibody. Dengue done conventional or real-time reverse transcriptase-PCR. The were describe distribution with respect age patient, duration on day blood collection month year. Zip codes used spatial plotting.Out 24,474 received its districts (Hooghly, Howrah, North South 24 Parganas), 38.3 per cent (95% confidence interval: 37.7-38.9%) screened positive dengue. correlation between positivity found be weak. A combination IgM antibody may better option detecting compared single test. Most AFI cases tested August November during study period, maximum noted September (45.9%). predominant serotype 2016, virus 1 (DENV-1), almost entirely replaced DENV-2 2017 2018.Dengue continues an important cause region round-the-year preventive measures are required control. Serotype switching is alarming should monitored routinely.