Evaluation of macular and peripapillary vascular parameter change in healthy subjects after caffeine intake using optical coherence tomography angiography
foveal avascular zone vessel density
Special Focus, Retina, Original Article
superficial macular vessel density
Retinal Vessels
RE1-994
deep macular vessel density
Healthy Volunteers
3. Good health
Ophthalmology
03 medical and health sciences
0302 clinical medicine
Caffeine
Humans
Prospective Studies
radial peripapillary capillary vessel density
Fluorescein Angiography
Tomography, Optical Coherence
caffeine
DOI:
10.4103/ijo.ijo_1989_21
Publication Date:
2022-02-25T13:01:36Z
AUTHORS (6)
ABSTRACT
Purpose:
To observe the effects of caffeine intake on vessel densities in macular and peripapillary regions and to analyze the correlations of vascular properties of these two interlinked regions in healthy volunteers using optical coherence tomography angiography (OCTA).
Methods:
In this prospective randomized, double-masked, placebo-controlled study, 120 participants were grouped into two groups: sixty subjects as a study group, which received caffeine and sixty subjects as a placebo group, which received a placebo. OCTA imaging was performed at baseline and 1 h after drug intake. Changes in macular and radial peripapillary capillary (RPC) vessel densities (VD) and foveal avascular zone (FAZ) parameters and correlation of these parameters were analyzed.
Results:
Baseline macular and RPC VD and FAZ parameters showed no significant difference between study and placebo groups (P > 0.05 for all). VD parameters in all segments of superficial and deep macular regions and peripapillary region showed a statistically significant decrease after caffeine intake (P < 0.001 for all). All macular superficial VD parameters showed a positive correlation with deep perifovea VD (P < 0.05 for all). Also, superficial perifovea VD was positively correlated with all deep macular VD parameters except deep fovea VD (P < 0.05 for all).
Conclusion:
We show that caffeine causes a decrease in macular and peripapillary vessel densities in healthy subjects, and correlations were observed between macular and peripapillary VD parameters. We believe that future studies are needed to support the effect of caffeine on peripapillary VD and the idea of using deep perifovea VD as the main parameter to estimate superficial macular parameters.
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CITATIONS (6)
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