Evaluation of macular and peripapillary vascular parameter change in healthy subjects after caffeine intake using optical coherence tomography angiography

• DOI: 10.4103/ijo.ijo_1989_21
• Publication Date: 2022-02-25T13:01:36Z
• Authors: Busra Yilmaz Tugan; Sevgi Subasi; Dilara Pirhan; Levent Karabas; Nursen Yuksel; Kubra Demirci Kucuk
• Keywords: Foveal avascular zone; Macula Lutea

Purpose: To observe the effects of caffeine intake on vessel densities in macular and peripapillary regions to analyze correlations vascular properties these two interlinked healthy volunteers using optical coherence tomography angiography (OCTA). Methods: In this prospective randomized, double-masked, placebo-controlled study, 120 participants were grouped into groups: sixty subjects as a study group, which received placebo placebo. OCTA imaging was performed at baseline 1 h after drug intake. Changes radial capillary (RPC) (VD) foveal avascular zone (FAZ) parameters correlation analyzed. Results: Baseline RPC VD FAZ showed no significant difference between groups ( P > 0.05 for all). all segments superficial deep region statistically decrease < 0.001 All positive with perifovea Also, positively correlated except fovea Conclusion: We show that causes subjects, observed parameters. believe future studies are needed support effect idea main parameter estimate