Antihypercholesterolemic and antiatherosclerotic potencies of Pandanus tectorius fruits via increasing scavenger receptor-B1 genes expression and inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

• DOI: 10.4103/japtr.japtr_164_19
• Publication Date: 2020-02-06T12:11:00Z
• Authors: Yosie Andriani; Gul-e-Saba Chaudhry; Efriyana Oksal; Inten Pangestika; NadiaMadiha Ramli; Habsah Mohamad; Rina Elvia; Hermansyah Amir; Effendy AWM; YeongYik Sung; TengkuSifzizul Te...
• Keywords: Scavenger Receptor; Coenzyme A

Atherosclerosis is a leading cause of death worldwide. The adverse side effects currently available drugs urge to find more effective and safe remedial agents. Alternative candidates from natural resources are great consequence in the emerging new drugs. Pandanus tectorius (Pandanaceae) was traditionally used Ayurvedic medicine cure certain diseases. Thus, current study conducted elucidate potency P. fruit as antiatherosclerosis antihypercholesterolemia agents through regulation high density lipoprotein (HDL) receptor (scavenger [SR]-B1) gene expression 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) vitro, respectively. noncytotoxic against HepG2 cell line confirmed by 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide assay. successfully upregulates SR-B1 downregulate HMGCR. Moreover, an vivo showed that has good activity on upregulation HDL subsequently downregulation total cholesterol level. did not show any increase toxicity biomarkers serum glutamic oxaloacetic transaminase glutamate pyruvate vivo. These results found fruits have preventive agent for hypercholesterolemia atherosclerosis via HMGCR mechanisms action.