Synthesis and cytotoxicity of the boron carrier pentagamaboronon-0-ol for boron neutron capture therapy against breast cancer

• DOI: 10.4103/japtr.japtr_220_21
• Publication Date: 2024-05-27T15:31:50Z
• Authors: Rohmad Yudi Utomo; Febri Wulandari; Dhania Novitasari; Ratna Asmah Susid...; Mitsunori Kirihata; Adam Hermawan; Edy Meiyanto
• Keywords: Neutron capture

Boronic acid-containing curcumin analog, pentagamaboronon-0 (PGB-0), acts as a potential boron-carrier agent but has limited water solubility. Thus, new compound (PGB-0-ol) with better chemical and pharmacological properties than PGB-0 been synthesized. Molecular docking was performed using molecular operating environment. Prediction of PGB-0-ol absorption, distribution, metabolism, excretion (ADME) pkCSM software. synthesized by adding NaBH