Severe aortic valve stenosis: Symptoms, biochemical markers, and global longitudinal strain

• DOI: 10.4103/jcecho.jcecho_13_20
• Publication Date: 2020-11-05T11:09:24Z
• Authors: Paolo Zappulla; Giuseppe Bottaro; Wanda Deste; Francesca Famà; Federica Agnello; Danilo Trovato; Antonio Indelicato; Marco Barbanti; Carmelo Sgroi; InesP Monte; Corrado Tamburino
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Article; B‐type natriuretic peptides, left ventricular global longitudinal strain, severe aortic valve stenosis; 3. Good health

Background: According to the actual guidelines regarding severe aortic valve stenosis (AS), symptoms are most important trigger for replacement (AVR). However, objective analysis of cardiological clinic can be confused, considering aging population this disease affects and comorbidities. Objectives: Looking an marker disease, useful scheduling correct AVR, we researched relation between some biochemical markers left ventricular (LV) dysfunction its global longitudinal strain. Materials Methods: We analyzed 74 consecutive patients (82 ± 4 years) with AS. identified 61 (angina, dyspnea, syncope) 13 asymptomatic patients. The clinical echocardiographic parameters were compared these two groups. LV ejection fraction (LVEF), strain (LVGLS), NT-pro-B-type brain natriuretic peptide (BNP), troponin T (TNT), creatine kinase-MB (CPK-MB), myoglobin determined at time evaluation. Results: Compared group, in symptomatic group had a lower LVGLS (P = 0.002) increased pro-BNP 0.0002). showed good correlation as myocardial damage, linear increase decrease (r 0.43). Despite normal value LVEF > 50% patients, them (46%) have early LVGLS. No other statistically significant difference emerged from analysis, TNT 0.29), CPK-MB 0.36), 0.38). Conclusions: Pro-BNP considered severity AS management especially