Increased risk of acute pancreatitis in patients with sjögren syndrome: A nationwide population-based cohort study

• DOI: 10.4103/jmedsci.jmedsci_58_19
• Publication Date: 2019-05-30T11:28:00Z
• Authors: Wu-Chien Chien; Chung-Kan Peng; Ming-Tsung Chen; Chung-Kuang Yao; Chi-Hsiang Chung; Chih-Hao Shen; Sheng-Huei Wang; Chih-Hsin Wang
• Keywords: 03 medical and health sciences; sjögren syndrome; 0302 clinical medicine; acute pancreatitis; RC86-88.9; R; Medicine; autoimmune diseases; Medical emergencies. Critical care. Intensive care. First aid; 3. Good health

Background: Sjögren's syndrome (SS) is a chronic autoimmune disease with lymphocytic exocrine gland infiltration causing dry mouth and eyes. The can develop alone (primary SS, PSS) or other diseases (secondary SSS). PSS has been suggested to increase the acute pancreatitis risk. However, whether all patients SS share this higher risk remains uncertain. This nationwide population-based cohort study aimed detect associations between pancreatitis. Methods: We identified 11,922 individuals 47,688 without (non-SS cohort) 2000 2010 from Taiwan National Health Insurance database. matched non-SS cohorts according age, gender, index year at 1:4 ratio. used Cox multivariable proportional-hazards model determine effects of on Results: had than after covariate adjustments (adjusted hazard ratio [HR], 3.374; 95% confidence interval [CI], 2.869–3.969). Patients exhibited 2.872-fold (95% CI, 2.611–3.901) SSS 4.121-fold 3.752–5.124) for Our subgroup analyses revealed that systemic lupus erythematosus HR, 3.85; 3.259–4.999), rheumatoid arthritis 4.298; 3.862–5.286), sclerosis 2.765; 2.26–3.68), polymyositis 2.641; CI,1.847–3.101) dermatomyositis 3.77; 2.894–4.502) Conclusions: presented increased risks PSS. Physicians should be aware in SS.