Expert Opinion on the Identification and Pharmacological Management of Worsening Heart Failure

• DOI: 10.4103/jpcs.jpcs_32_23
• Publication Date: 2024-06-01T18:57:52Z
• Authors: Sandeep Seth; Johann Bauersachs; Sanjay Mittal; Vishal Rastogi; Rajeev Kumar Rajput; Dheeraj Gandotra; Ripen Gupta; Manoj Sahu; S N Pathak; Mohit Bhagwati; Simmi Minocha; Pawan Sharma; Deepankar Vatsa; Raghav Aggarwal; Gyanti R B Singh; Gaurav Arora; Samir Kubba; Meera Rajeev; Pratik Jha; B S Vivek; Mohit Gupta; Rameshwar Bishnoi; Rashi Khare; Vipul Gupta; Naresh Kumar Goyal; Aseem Dhall; Amit Madan; B D Sharma; Atul D Abhyankar; Pravin Kahale; Talha Meeran; Babu Ezhumalai; B C Kalmath; V T Shah; Sandip Rungta; P Ashok Kumar; Sunil Christopher; Alok A Shah; Ramesh Dargad; Kaushik Sheth; Abhay Khode; Sunil P Mehta; Bommareddy V A Ra...; Puneet Gupta; B K Tripathi; Ritwick Raj Bhuyan
• Keywords: RD1-811; worsening heart failure; RC666-701; vericiguat; R; guideline directed medical therapy; heart failure hospitalization; Medicine; Diseases of the circulatory (Cardiovascular) system; heart failure with reduced ejection fraction; Surgery

Worsening heart failure (WHF) is a distinct under-diagnosed and under-treated condition, independent of location of care. Heart failure (HF) progression is punctuated by repeated WHF events, each resulting in reduced cardiac function. One-third of the patients with HF with reduced ejection fraction experience a decompensation event. These decompensation events often result in the emergency department visits and HF hospitalization. Despite its inclusion in recent guidelines, there is no precise definition of WHF or its various forms. It is worth noting that WHF signals a need for treatment optimization as per guideline-directed medical therapy and the addition of novel drugs like a stimulator of soluble guanylate cyclase that benefit this high-risk patient population. This practical document is based on the expert opinion of cardiologists, cardiothoracic surgeons, and physicians that discussed the definition, assessment, pharmacological management, and monitoring of WHF patients in a hospitalized setting. In addition, there is also a need for an expert opinion for the management of WHF in an outpatient setting.