Myocardial damage in multisystem inflammatory syndrome associated with COVID-19 in children and adolescents

• DOI: 10.4103/jrms.jrms_1195_20
• Publication Date: 2021-11-29T05:53:52Z
• Authors: Vladislav Vukoman...; Stasa Krasic; Sergej Prijic; Gordana Petrovic; Sanja Ninic; Sasa Popovic; Ivana Cerovic; Snezana Ristic; Dejan Nesic
• Keywords: Dilated Cardiomyopathy

Background: In multisystem inflammatory syndrome in children (MIS-C) temporarily associated with coronavirus disease-19 (COVID-19), myocardial damage has been reported. Materials and Methods: A retrospective observational cohort study included under 18 who had a injury related to COVID-19 treated mother child health institute from April 2020 August 2020. Myocardial was manifested by elevated serum cardiac troponin NT-proBNP LV dysfunction, arrhythmias, coronary arteries (CAs) dilatation or aneurysms. During the short-term follow-up, testing (electrocardiography, laboratory analysis, echocardiography, 24-h Holter monitoring, exercise stress test, magnetic resonance) performed. Results: Six male adolescents (14.7 ± 2.4 years) were analysis (2/6 MIS-C shock syndrome). All patients acute-phase reactants NT-proBNP, whereas troponins 5/6 patients. Echocardiography revealed left ventricular (LV) systolic dysfunction (EF 45.2 6.9%); 2/6 dilated CAs. IVIG prescribed all MIS-C. Four required inotropic drug support. hospitalization, significant reduction of CRP, LDH, D-dimer ( P < 0.05) registered. function recovery registered 3 days after applied therapy 0.001). None developed cardiomyopathy CA Conclusions: With early recognition adequate therapy, recovered entirely, maintained follow-up period.