Exploring the Effect of Exercise versus Metformin on Insulin Resistance amongst Nigerians with Pre-diabetes: A Randomised Controlled Trial

• DOI: 10.4103/npmj.npmj_148_24
• Publication Date: 2024-09-02T08:01:03Z
• Authors: Umar Musa Tambuwal; Sabir Anas Ahmad; Umar Hayatu; Maiyaki Abubakar ...; Jimoh Ahmed Kolawale; Sada Kabiru Bello; Abdullahi Faruk Umar
• Keywords: Nigerians

Background: Pre-diabetes is an important risk factor for the development of type 2 diabetes and common in Nigeria. Effective intervention can reverse underlying pathogenesis insulin resistance pre-diabetes. This study aimed to determine compare impact moderate exercise metformin interventions on among participants with Materials Methods: Using a randomised placebo-controlled design, 54 Nigerians pre-diabetes were selected using simple random sampling. They offered metformin, or placebo treatment followed up 12 weeks. Insulin was assessed before after outcome compared. Results: Forty-nine completed study. Participants both groups had significantly decreased compared weeks intervention. However, there decrease by 77.3% (homeostasis model assessment-insulin [HOMA-IR]) increase sensitivity 81.2% (quantitative check index [QUICKI]) group. In comparison, group 66.3% (HOMA-IR) 76.2% (QUICKI). Conclusion: Amongst pre-diabetes, have higher efficacy than improving resistance. improved more this need be longer period assess long-term effects these interventions.