Role of tunneling nanotubes in neuroglia

• DOI: 10.4103/nrr.nrr-d-24-01129
• Publication Date: 2025-03-28T04:11:28Z
• Authors: Weichen Xu; Xingyu Yang; Hongmei Zheng; Changzheng Chen; Jiajia Yuan
• Keywords: Neuroglia

Tunneling nanotubes are crucial structures for cellular communication and observed in a variety of cell types. Glial cells, the most abundant cells nervous system, play vital role intercellular signaling can show abnormal activation under pathological conditions. Our bibliometric analysis indicated substantial increase research on tunneling over past two decades, highlighting their important communication. This review focuses formation various types glial including astrocytes, microglia, glioma Schwann as well roles cargo transport. We found that influence stability neural system nerve regeneration through nanotubes. facilitate transmission progression diseases by transporting pathogens harmful substances. However, they also involved alleviating stress removing toxins delivering essential nutrients. Understanding interactions between could provide valuable insights into complex networks govern brain function responses to injury.