Ultrashort wave therapy promotes traumatic brain injury recovery by suppressing neuroinflammation

• DOI: 10.4103/nrr.nrr-d-24-01479
• Publication Date: 2025-05-14T07:00:25Z
• Authors: Chuang Xu; Jinwei Liu; Qiaozhen Qin; Heyang Zhang; Xiaotong Li; Yue Chen; Zhenhua Xu; Fang Wang; Nihui Zhang; Zhen Zhang; Yifei Tan; Lingyu Zhang; Guilin Chen; Liu Liu; Weiwei Xing; Yan Wang; Huaqiang Ruan; Xiaoxia Jiang; Nan Peng
• Keywords: Traumatic Injury

Abstract Despite growing treatments for traumatic brain injury, there is still no ideal strategy efficiently mitigating these processes. Ultrashort wave therapy, a type of physical factor has been widely used in various clinical treatments. However, its effects on injury and the underlying mechanisms are not well understood. In this study, we demonstrate that ultrashort treatment can significantly promote repair alleviate emotional cognitive disorders. Our data showed reduced levels pro-inflammatory factors inhibited neuroinflammation. vitro experiments activation C8-D1A astrocytes BV2 microglia. Furthermore, induced expression Piezo1, while effectively suppressed high expression. Administration Yoda1, Piezo1 agonist, to mice reversed beneficial wave. Consistently, Yoda1 also inhibitory effect astrocytes. These findings indicate an therapeutic which works by inhibiting reducing neuroinflammation, promoting nerve after injury.