Bone mineral density loss in patients with cirrhosis

• DOI: 10.4103/sjg.sjg_74_18
• Publication Date: 2018-11-19T09:31:58Z
• Authors: Fahad Alsohaibani; IbrahimN Muhsen; Omar AlFreihi; Faisal Abaalkhail; Abdullah AlKhenizan; Mohammed Khan; Abdelmoneim Eldali
• Keywords: Osteopenia; Densitometry; Liver disease; Chronic liver disease; Univariate analysis

<br><b>Background/Aims:</b> Evidence of increased risk osteoporosis and osteopenia in chronic liver disease cirrhosis is inconsistent. This study aims to investigate this relationship identify the predictors loss bone mineral density Saudi patients.<br><b>Patients Methods:</b> One hundred sixty-four patients controls who are age gender matched, were included with 1:1 ratio. Patients' adults confirmed cirrhosis. Bone densitometry (BMD) at both lumbar spine (LS) femoral neck (FN) collected for groups. Univariate multivariate regression analyses performed BMD loss.<br><b>Results:</b> Results showed that cirrhotic higher developing or LS (OR 2.23, 95% CI [1.19–4.19], <i>P</i> = 0.01) but not FN, when compared control sample. Patients found have lower vitamin D PTH levels (<i>P</i> 0.0005) 0.006), respectively. Of possible tested (gender, age, body mass index [BMI], phosphorus, calcium, parathyroid hormone (PTH), D, Model End Stage Liver Disease [MELD] score), female was main predictor only 4.80, [1.47–15.73], 0.01).<br><b>Conclusions:</b> The susceptibility having decreased BMD, particularly it highlights need preventive measures, especially patients.<br>