BIRB 796 has Distinctive Anti-inflammatory Effects on Different Cell Types

• DOI: 10.4110/in.2013.13.6.283
• Publication Date: 2013-12-28T04:41:32Z
• Authors: Soyoon Ryoo; Jida Choi; Jaemyung Kim; Suyoung Bae; Jaewoo Hong; Seunghyun Jo; Soohyun Kim; Youngmin Lee
• Keywords: Cell type

The pro-inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin (IL)-1β are crucial mediators involved in chronic inflammatory diseases. Inflammatory signal pathways regulate cytokine expression-mediated by p38 mitogen activated protein kinase (p38MAPK). Therefore, considerable attention has been given to p38MAPK as a target molecule for the development of novel anti-inflammatory therapeutics. BIRB 796, one inhibitor, is candidate therapeutic drug In this study, we investigated effect 796 on productions lipopolysaccharide (LPS) different immune cell types. reduced LPS-mediated IL-8 production THP-1 cells but not Raw 264.7 cells. Further analysis molecules western blot revealed that sufficiently suppressed phosphorylation both types whereas it failed block inhibitor kappa B (I-κB) degradation Taken together, these results suggest function depends