Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines

• DOI: 10.4110/in.2024.24.e19
• Publication Date: 2024-06-28T08:16:43Z
• Authors: Sang-Hyun Kim; Erica Españo; Bill Thaddeus Pad...; Ju-Ho Son; Jihee Oh; Richard J. Webby; Young-Ran Lee; Chan-Su Park; Jeong-Ki Kim
• Keywords: Original antigenic sin

The influenza virus poses a global health burden. Currently, an annual vaccine is used to reduce virus-associated morbidity and mortality. Most vaccines have been developed elicit neutralizing Abs against virus. These primarily target immunodominant epitopes derived from hemagglutinin (HA) or neuraminidase (NA) of the incorporated in vaccines. However, HA NA are highly variable proteins that prone antigenic changes, which can efficacy. Therefore, it essential develop universal conserved regions virus, enabling cross-protection among different variants. internal serve as ideal targets for presented by MHC class I molecules on Ag-presenting cells, such dendritic recognized CD8 T cell responses, reducing likelihood disease viral spread inducing virus-infected apoptosis. In this review, we highlight importance cell-mediated immunity viruses developing cell-based