IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials

• DOI: 10.4110/in.2024.24.e2
• Publication Date: 2024-02-29T06:48:20Z
• Authors: Choong-Hyun Koh; Byung-Seok Kim; Chang-Yuil Kang; Yeonseok Chung; Hyungseok Seo

Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in modulation of a wide range immune responses. serves critical defender against bacterial fungal pathogens, while maintaining symbiotic relationships with commensal microbiota. However, alterations its levels can lead to chronic inflammation autoimmunity. IL-21, on other hand, bridges adaptive innate responses, imbalance is implicated autoimmune diseases cancer, highlighting important role both health disease. Delving into intricacies these not only opens new avenues for understanding system, but also promises innovative advances development therapeutic strategies numerous diseases. In this review, we will discuss an updated view immunobiology potential IL-21.