Prognostic significance of preoperative and follow-up neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with non-metastatic clear cell renal cell carcinoma

• DOI: 10.4111/icu.2019.60.1.14
• Publication Date: 2019-01-03T02:47:24Z
• Authors: Tae Woo Kim; Jung Hwan Lee; Kang Hee Shim; Seol Ho Choo; Jong Bo Choi; Hyun Soo Ahn; Se Joong Kim; Sun Il Kim
• Keywords: Univariate analysis; Clinical Significance; Prognostic variable

Purpose: To evaluate the significance of preoperative and follow-up neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) as prognostic factors for recurrence in patients with non-metastatic clear cell renal carcinoma (NMCCRCC). Materials Methods:We retrospectively reviewed medical records 309 NMCCRCC who underwent radical or partial nephrectomy.The various clinicopathological variables, NLR (pNLR) PLR (pPLR), at quasi-recurrence (rNLR rPLR) recurrence-free survival (RFS) was analyzed.Results: At mean 93 months, 44 (14.2%) developed recurrence.In univariate analysis, clinical presentation, tumor size, pathologic stage, Fuhrman grade, pNLR, pPLR rNLR were significant RFS.In multivariate analysis using pNLR continuous stage independent dichotomous grade ≥1.7 analyses rPLR, only size a subset least 42 months without recurrence, ≥1.9 significantly associated worse RFS, albeit significance.Conclusions: are RFS NMCCRCC.We propose that postoperative 1.9 higher one more adverse should prompt radiologic evaluation possible metastasis.