Effect of long-term postoperative OM-89 administration on bacteriuria from suspected infectious stones

• DOI: 10.4111/icu.20250086
• Publication Date: 2025-04-29T23:42:34Z
• Authors: Seung-Ju Lee; Jemo Yoo; Hee Youn Kim; Jin Bong Choi; Dong Sup Lee

We aimed to evaluate the effect of long-term oral OM-89 therapy on urinary microflora in patients with urolithiasis. Patients underwent surgical removal stones followed by no treatment for six months or daily administration. Urine culture and polymerase chain reaction (PCR) were performed at baseline visit (V1) 2 (V2) 6 (V3) after operation. A total 113 completed study. The rate bacteria detection urine V3 did not differ between treated untreated groups (p>0.999); however, PCR tended be higher group than (p=0.052). Escherichia coli Enterococcus spp. most commonly detected via both all timepoints. Risk factors positive V1 (p=0.048) female sex (p=0.048), whereas was associated (p=0.023), V2 (p<0.001), (p=0.038). use decreased rates bacterial a further decrease V3. Long-term immunization could frequency colonization stones. used as complementary if retrieved stone is suspected related infection.