Lessons learned from the first 2 years of experience with thyroid core needle biopsy at an Indonesian national referral hospital

• DOI: 10.4132/jptm.2025.02.19
• Publication Date: 2025-04-25T07:46:41Z
• Authors: Agnes Stephanie H...; Maria Francisca Ham; Retno Asti Werdhani; Erwin Danil Julian; Rafi Ilmansyah; Chloe Indira Arfe...; Tri Juli Edi Tarigan
• Keywords: Core biopsy

Core needle biopsy (CNB) improves diagnostic accuracy by providing precise tissue sampling for histopathological evaluation, overcoming the limitation of inconclusive fine-needle aspiration results. This study evaluated performance CNB in assessing thyroid nodules, with additional analysis benefits BRAF V600E and RAS Q61R immunohistochemical (IHC) markers. retrospective enrolled patients nodules who underwent at Dr. Cipto Mangunkusumo Hospital, Jakarta, from July 2022 to 2024. diagnoses were classified using Korean Thyroid Association Criteria. Diagnostic efficacy was neoplastic malignant lesions, both independently IHC. The correlation between nodule size postoperative diagnosis also analyzed. A total 338 samples included, 52.7% as category II. In 104 diagnoses, IV most prevalent (39.4%). demonstrated a sensitivity 74% specificity 100% lesions 23.8% lesions. Combining Q1R IHC increased 77% 28.8% Larger (>3 cm) significantly associated (p = .005) .004). performs well identifying or without IHC, but its low warrants caution. While categories V-VI indicate malignancy, possibility malignancy I-IV should not be overlooked.