Lipoprotein Glomerulopathy Associated with a Mutation in Apolipoprotein E

• DOI: 10.4137/ccrep.s12209
• Publication Date: 2013-12-05T19:54:08Z
• Authors: Riccardo Magistroni; Marco Bertolotti; Luciana Furci; Rita Adriana Fano; Marco Leonelli; Livia Pisciotta; Elisa Pellegrini; Laura Calabresi; Stefano Bertolini; Sebastiano Calandra
• Keywords: Apolipoprotein E; Hyperlipidemia; Glomerulopathy

Lipoprotein glomerulopathy is a pathological condition characterized by lipid accumulation in the glomerular capillaries that has been associated with presence of rare mutants apolipoprotein E (ApoE). We describe 51-year-old Italian patient presenting Type III hyperlipidemia and proteinuria whom renal biopsy showed capillary ectasia intraluminal deposits, suggesting diagnosis lipoprotein glomerulopathy. The patient, who had elevated plasma ApoE level, was found to be heterozygous for mutation (Arg150Cys), designated apoE MODENA . This induces formation dimers are detectable under non-reducing conditions. Treatment hypolipidemic drugs did not result complete remission accompanied slow but progressive worsening function persistence intracapillary thrombi. introduction low-density aphaeresis combined more aggressive lowering antihypertensive therapy resulted substantial improvement function. Switching from filtration an equivalent control damage. died intracranial hemorrhage during acute episode malignant hypertension.