Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment

• DOI: 10.4137/idrt.s38108
• Publication Date: 2016-03-20T20:55:10Z
• Authors: Oluwaseun Ogunwuyi; Namita Kumari; Kahli A. Smith; Oleg Bolshakov; Simeon Adesina; Ayele Gugssa; Winston A. Anderson; Sergei Nekhai; Emmanuel O. Akala
• Keywords: Raltegravir; Nevirapine; Zeta potential

Highly active antiretroviral (ARV) therapy (HAART) for chronic suppression of HIV replication has revolutionized the treatment HIV/AIDS. HAART is no panacea; treatments must be maintained life. Although great progress been made in ARV therapy, continues to replicate anatomical and intracellular sites where drugs have restricted access. Nanotechnology considered a platform circumvent some challenges HIV/AIDS treatment. Dispersion polymerization was used fabricate two types (PMM ECA) polymeric nanoparticles, each successfully loaded with four (zidovudine, lamivudine, nevirapine, raltegravir), followed by physicochemical characterization: scanning electron microscope, particle size, zeta potential, drug loading, vitro availability. These nanoparticles efficiently inhibited HIV-1 infection CEM T cells peripheral blood mononuclear cells; they hold promise The ARV-loaded polyethylene glycol on corona may facilitate tethering ligands targeting specific receptors expressed reservoirs.