Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice

• DOI: 10.4142/jvs.2012.13.4.339
• Publication Date: 2013-01-04T05:05:46Z
• Authors: Sun-Gil Do; Jun-Hong Park; Hajin Nam; Jin-Bong Kim; Jae-Yong Lee; Yang-Seok Oh; Jun-Gyo Suh
• Keywords: Fibroin

Components of silk including fibroin have long been used as anti-diabetic remedies in oriental medicine.However, detailed mechanisms underlying these antidiabetic effects remain unclear.In this study, we examined the activity hydrolysate (SFH) C57BL/KsJ-db/db (db/db) mice, a well-known animal model non-insulin dependent diabetes mellitus.When db/db mice were administered SFH drinking water for 6 weeks, hyperglycemia animals gradually disappeared and level glycosylated hemoglobin decreased, indicating that plays important role reducing symptoms diabetes.In addition, SFH-treated exhibited improved glucose tolerance with increased plasma insulin levels.Immunohistochemical morphological analyses showed up-regulated production by increasing pancreatic β cell mass mice.In summary, our results suggest exerts mellitus mouse model.