Use of aglepristone for the treatment of P4induced insulin resistance in dogs

• DOI: 10.4142/jvs.2014.15.2.267
• Publication Date: 2014-06-26T09:34:45Z
• Authors: Enrico Bigliardi; Carla Bresciani; Daniela Callegari; Francesco Di Ianni; Giorgio Morini; Enrico Parmigiani; Ezio Bianchi
• Keywords: Blood Glucose; Radioimmunoassay; diestru; Estrous Cycle; 630; 0403 veterinary science; Dogs; Pregnancy; insulin resistance; Diabetes Mellitus; Animals; Hypoglycemic Agents; Dog Diseases; Estrenes; diabetes mellitu; aglepristone; 600; 04 agricultural and veterinary sciences; bitche; 3. Good health; Original Article; Female; Insulin Resistance; Receptors, Progesterone

Insulin resistance (IR) in dogs is suspected when hyperglycemia present despite administration of insulin doses greater than 1.0 to 1.5 UI/kg. IR caused by increases counter regulatory hormones concentrations (glucagon, glucocorticoids, catecholamines and growth hormone). This study was conducted investigate the use aglepristone (RU 46534), a P4 receptor antagonist, for treatment diabetes mellitus bitches during luteal phase. All animals were treated with porcine zinc suspension (Caninsulin) (Alizin) 10 mg/kg subcutaneously at day 1, 2, 9 17 from diagnosis. At 5, no significant variation glycemia shown. 12 20, serum glucose lower (p < 0.05). From dose reduced 0.8 IU BID. following weeks controlled.