The changes of immune-related molecules within the ileal mucosa of piglets infected with porcine circovirus type 2

• DOI: 10.4142/jvs.2020.21.e78
• Publication Date: 2020-09-17T00:23:59Z
• Authors: Fengyang Shi; Qiuming Li; Zhanming Zou; Yang Wang; Xiaolin Hou; Yonghong Zhang; Qinye Song; Shuanghai Zhou; Huanrong Li
• Keywords: Lamina propria; Intestinal mucosa; Immunoglobulin A

Enteritis is one of the most frequently reported symptoms in piglets infected with porcine circovirus type 2 (PCV2), but immunopathogenesis has not been reported.This study examined effect a PCV2 infection on intestinal mucosal immune function through morphological observations and immune-related molecular detection.Morphological changes within ileum during were observed. The expression related-molecules was analyzed using gene chip. immunocyte subsets by flow cytometry. secretory immunoglobulin A (SIgA) content enzyme-linked immunosorbent assay.The caused ileal villus damage, epithelial cells exfoliation, an increase lymphocytes lamina propria at 21 days post-infection. Differentially expressed genes occurred defense response, inflammatory complement coagulation cascade reactions. Most them downregulated significantly induction site upregulated effector site. associated SIgA production In contrast, Toll-like receptor-related frequencies dendritic cells, B CD8⁺T sites. decreased mucosa.PCV2 infections can cause damage to that expression, cell subsets, production. These findings elucidated after from perspective immunity, which provides insights into further for PCV2-induced enteritis.