Estimation of Population Attributable Fraction by Hormone and Reproductive Factors on Female Cancer in the Republic of Korea, 2015 to 2030

• DOI: 10.4143/crt.2024.707
• Publication Date: 2024-11-19T01:30:26Z
• Authors: Youjin Hong; Soseul Sung; Woojin Lim; Sungji Moon; Kwang-Pil Ko; Jung Eun Lee; Inah Kim; Sun Ha Jee; Sun-Seog Kweon; Min-Ho Shin; Sangmin Park; Seung-Ho Ryu; Sun Young Yang; Jeongseon Kim; Sang-Wook Yi; Yoon-Jung Choi; Jeong-Soo Im; Hong Gwan Seo; Sue K. Park
• Keywords: Hormone Therapy

Purpose Population attributable fractions (PAFs) for hormone and reproductive factors have been estimated in several countries. IARC designated as Group 1 2A carcinogen breast, ovarian, endometrial uterine cervix cancer. This study aimed to estimate the PAFs of hormone/reproductive factor attributed cancer incidence deaths Korean women projected trends from 2015 2030. Materials Methods The PAF was with using 2005 standardized prevalence rates 2020 a 15-year latency. Based on Levin's formula, were calculated Korea National Health Nutrition Examination Survey (KNHANES) relative risks (RRs), which risk selected female associated oral contraceptive, replacement therapy duration breastfeeding, meta-analysis studies performed population. Studies based Asian Global populations sensitivity analysis. Results estimation 1.02% 1,192 cases 2.67% 3,112 cases. Moreover, 0.40% (125 deaths) 1.09% (342 female-related order. EP combined HRT accounted most proportion breastfeeding factors. Also, breast had highest percent both Conclusion Through this study, will be reduced by encouraging avoiding use contraceptives (OCs) (HRT) more than 6 months Additionally, among four cancers observed significant level prevention.