Deciphering the Risk of Developing Lung Cancer After the Diagnosis of Gastric Cancer with Genetic Evidence: A European and East Asian Populations-Based Mendelian Randomization Analysis

• DOI: 10.4143/crt.2024.875
• Publication Date: 2025-04-18T04:31:21Z
• Authors: Jiansheng Chen; Aiming Zeng; Yunzhe Yu; Sida Sun; Liqun Liao; Siwei Huang; Zhongshan Yang; Junfeng Zhou; Weijie Wu
• Keywords: Mendelian Randomization; Mendelian inheritance

Lung cancer is frequently observed as a second primary malignancy following gastric cancer, yet the genetic causality between them remains uncertain. This study aims to evaluate causal relationship and lung cancers using Mendelian randomization (MR) analysis. Single nucleotide polymorphisms associated with were selected from Genome-Wide Association Study in East Asian European populations instrumental variables. The effects evaluated univariable multivariable MR analysis, inverse variance weighted (IVW) method serving criterion. Heterogeneity sensitivity analyses performed ensure robustness of findings. Univariable analysis demonstrated that susceptibility population was significantly an increased risk (IVW: OR:1.285, 95%CI:1.072-1.541, p=6.83E-03), which consistently validated (IVW:OR:1.356, 95% CI:1.114-1.651, p=2.40E-03). Multivariable further indicated significant positive persisted both after adjusting for confounding factors (all p<0.05). Conversely, no developing diagnosis either (p>0.05). confirms increases cancer. finding provides theoretical basis exploring underlying biological mechanisms suggests enhancing screening patients may be necessary improve patient prognosis.