Evaluation of Nomenclature of Fatty Liver Disease in Association with Hepatocellular Carcinoma: A 14.5-Year Cohort Study in Korea

• DOI: 10.4143/crt.2024.876
• Publication Date: 2025-02-11T08:28:58Z
• Authors: Tung Hoang; Jeonghee Lee; Bo Hyun Kim; Yuri Cho; Jeongseon Kim

Purpose New nomenclature has incorporated metabolic traits and/or alcohol intake history to replace nonalcoholic fatty liver disease (NAFLD). Concerning the performance of different terminologies in Asian population, this study aimed investigate risk developing hepatocellular carcinoma (HCC) persons meeting criteria for subclasses disease. Materials and Methods Between 2002 2021, 28,749 participants from cancer registry linkage, who had no prior HCC, were prospectively included. Fatty was defined using abdominal sonography index. Participants classified as having NAFLD, dysfunction–associated (MAFLD), dysfunction-associated steatotic (MASLD), with increased (MetALD), or alcohol-related (ALD) their association HCC investigated Cox regression models. Results During a median follow-up 14.5 years, 166 cases newly diagnosed. The prevalences NAFLD MASLD 19.7% 18.7%, respectively, whereas MAFLD observed 35.2% population. Given low proportion excessive consumption, we identified 3.3% MetALD 3.5% ALD cases. Overall, suggestively associated (hazard ratio, 1.40; 95% confidence interval 0.99-1.98). In contrast, results other not significant. Conclusion Our suggest importance both presence dysfunction relation need reconsider thresholds diagnostic within Korean