New mechanisms of vesicles migration

• DOI: 10.4149/gpb_2015048
• Publication Date: 2016-06-15T15:16:59Z
• Authors: Viviana Aursulesei; Decebal Vasincu; Daniel Timofte; Lucia Vrajitoriu; Irina Gatu; Dan D. Iacob; Vlad Ghizdovat; Calin Buzea; Maricel Agop
• Keywords: Multicellular organism

In multicellular organisms, both health and disease are defined by means of communication patterns involving the component cells. Despite intricate networks soluble mediators, cells also programed to exchange complex messages pre-assembled as multimolecular cargo membranous structures known extracellular vesicles (EVs). Several biogenetic pathways produce EVs with different properties able orchestrate neighboring cell reactions or establish an environment ripe for spreading tumor Such effect is in fact extension similar physiological roles played exosomes guiding migration under nontumoral tissue remodeling organogenesis. We start a biological thought experiment equivalent Bénard's experiment, fluid layer adherent matrix, haptotactic gradient, then, we build present first Lorenz model migration. Using Galerkin's method reducing system partial differential equations ordinary equations, developed. physical frame distributing individual molecular exosomal type cell-guiding cues matrix space could serve guide neoformation budding pattern tumoral instances.