Knockdown of microRNA-103a-3p inhibits the malignancy of thyroid cancer cells through Hippo signaling pathway by upregulating LATS1

• DOI: 10.4149/neo_2020_191224n1331
• Publication Date: 2020-08-04T17:07:47Z
• Authors: M. L. ZHANG; W. H. SUN; H. Q. WU; Z. D. LIU; P. WANG
• Keywords: Hippo signaling pathway

MicroRNA (miR)-103a-3p has been shown to be involved in the development and progression of several types cancer.However, role miR-103a-3p thyroid cancer remains unclear.This study investigated effects on biological characteristics cells related mechanisms.In present study, we found that expression was increased tissues compared non-cancerous tissues.Additionally, cell lines (TPC-1, SW579, BHT101, K1) markedly higher than human line (Nthy-ori3-1).Silencing obviously inhibited proliferation, migration, invasion promoted apoptosis BHT101 cells.miR-103a-3p upregulation K1 cells.Mechanistically, LATS1 identified as a functional target miR-103a-3p, negatively regulated expression.miR-103a-3p knockdown (or upregulation) partially reversed overexpression) apoptosis, cells.LATS1 phosphorylation YAP nuclear translocation YAP.Whereas, downregulation inhibitory effect Hippo signaling pathway.Moreover, overexpression induced inhibits YAP, this effect.The tumor growth vivo.Taken together, promotes through pathway by upregulating LATS1.