The loss of PTEN expression and microsatellite stability (MSS) were predictors of unfavorable prognosis in gastric cancer (GC)

• DOI: 10.4149/neo_2020_200422n427
• Publication Date: 2020-08-13T13:20:17Z
• Authors: J. P. FAN; J. QIAN; Y. J. ZHAO
• Keywords: Microsatellite Instability

The predictors for the prognosis of gastric cancer (GC) are not clear.We intended to explore role PTEN and microsatellite (MS) in GC, showing their potential as prognostic markers.Primary tissues, adjacent normal clinicopathological parameters 187 patients were collected.The expression level MS status classified by immunohistochemistry (IHC).The relationship among indicators was compared chi-square test.The survival curves delineated Kaplan-Meier tested Log-rank methods.The impact multiple factors on determined COX proportional hazards model.Significantly, associated with lymphatic invasion (p=0.011) Lauren grade (p=0.015).MS differentiation (p=0.006) grades (p=0.035).TNM stage under positive (p=0.014).Patients stability (MSS) had worse median overall (OS) than that instability (MSI) (p=0.013).Patients negative a OS (p<0.001).The tumor subtype negative-MSS (p<0.001) negative-MSI (p=0.042) strong poor survival.Negative MSS might lead unfavorable due association GC.PTEN could be GC.