Novel Pyrazoles As Potent Growth Inhibitors of Staphylococci, Enterococci and Acinetobacter Baumannii Bacteria

• DOI: 10.4155/fmc-2021-0140
• Publication Date: 2021-12-08T10:40:44Z
• Authors: Ibrahim Alkhaibari; Hansa Raj KC; Duminduni H Angap...; David Gilmore; Mohammad A Alam
• Keywords: Acinetobacter baumannii

Background: Methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and Acinetobacter baumannii cause serious antibiotic-resistant infections. Finding new antibiotics to treat these infections is imperative for combating this worldwide menace. Methods & Results: In study, the authors designed synthesized potent antimicrobial agents using 4-trifluoromethylphenyl-substituted pyrazole derivatives. addition their potency against planktonic bacteria, compounds effectively eradicated S. aureus Enterococcus faecalis biofilms. Human cells tolerated with good selectivity factors. Furthermore, provide evidence mode of action based on time-kill kinetics, flow cytometry analysis propidium iodide-treated bacteria oxygen uptake studies. Conclusion: This study demonstrated 20 novel antibacterial activity that are by human cell lines.