Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migration

• DOI: 10.4161/cam.5.5.18162
• Publication Date: 2011-10-05T15:42:17Z
• Authors: Erin M. McAuley; Tiffany A. Bradke; George E. Plopper
• Keywords: Cytostasis; CDC42; Phenylboronic acid

Previous studies from our lab have shown that both boric (BA) and phenylboronic- acid (PBA) inhibit the migration of prostate cancer cell lines, as well non-tumorigenic cells. Our results indicate PBA is more potent than BA in targeting metastatic proliferative properties Here we focus on impact Rho family GTP-binding proteins their downstream targets. Treatment with 1mM decreases activities RhoA, Rac1, Cdc42 DU-145 cells, but not normal RWPE-1 Furthermore, ROCKII activity phosphorylation myosin light chain kinase decrease a result either or treatment suggesting these compounds target actomyosin-based contractility.