EGFR expression variance in paired colorectal cancer primary and metastatic tumors

• DOI: 10.4161/cbt.10.5.12610
• Publication Date: 2010-10-27T18:09:23Z
• Authors: Nirit Yarom; Celia Marginean; Terence Moyana; Ivan Gorn-Hondermann; H. Chaim Birnboim; Horia Marginean; Rebecca C. Auer; Micheal Vickers; Timothy R. Asmis; Jean Maroun; Derek Jonker
• Keywords: Expression (computer science); Primary (astronomy)

Background: Previous studies indicate that drugs targeting the Epidermal Growth Factor Receptor (EGFR) signaling pathways can induce objective responses, prolong time to progression and improve survival of patients with metastatic colorectal cancer (mCRC). EGFR expression in primary tumour may not predict response these agents data is conflicting regarding correlation site. In other sites, presence mutations was associated efficacy a subset patients.Objectives: The goal this study correlate between liver assess mutational status kinase domain.Methods: This single center retrospective who underwent surgical resection CRC, for whom paired paraffin-embedded tissue blocks tumours resected metastases were available. immunostaining mutation analyses preformed.Results: Fifty eight primaries available analysis. detectable 96.6% samples 89.7% samples. Perfect concordance intensity score found 46.5% cases. While individual pairs poorly concordant intensity, proportion intense staining similar Overall did either tumour, or metastasis. There 2 cases domain. Both exon21 C>T.Conclusions: analysis, tumor site predictive its level levels do appear be useful prognostic markers.