Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

• DOI: 10.4161/cbt.3.9.1038
• Publication Date: 2010-07-16T20:25:50Z
• Authors: Ilker Durak; Hasan Biri; Erdinç Devrim; Sinan Sözen; Aslıhan Avcı
• Keywords: Male; 0301 basic medicine; Adenosine Deaminase; Plant Extracts; Prostatic Neoplasms; Urtica dioica; DNA; 3. Good health; Plant Leaves; 03 medical and health sciences; Tumor Cells, Cultured; Humans; Enzyme Inhibitors

Investigation of possible effects of aqueous extract of Urtica dioica leaves on adenosine deaminase activity in prostate tissue from patients with prostate cancer.Ten prostate tissues from patients with pathologically proven localized prostate cancer (Gleason scores 4 to 7) were used in the study. In the tissues, ADA activities with and without preincubation with different amounts of Urtica dioica extracts were performed.Aqueous extract of Urtica dioica results in significant inhibition on adenosine deaminase (ADA) activity of prostate tissue.ADA inhibition by Urtica dioica extract might be one of the mechanisms in the observed beneficial effect of Urtica dioica in prostate cancer.