FBXW7 is involved in Aurora B degradation

• DOI: 10.4161/cc.22381
• Publication Date: 2012-10-22T21:06:38Z
• Authors: Chieh-Lin Teng; Yun-Chi Hsieh; Liem Phan; Jihyun Shin; Chris Gully; Guermarie Velazqu...; Stephen Skerl; Sai-Ching J. Yeung; Shih-Lan Hsu; Mong-Hong Lee
• Keywords: Aurora B kinase; Mitotic exit; Aurora inhibitor; Spindle checkpoint; Ectopic expression

FBXW7, a component of E3 ubiquitin ligase, plays an important role in mitotic checkpoint, but its remains unclear. Aurora B is checkpoint kinase that pivotal mitosis by ensuring correct chromosome segregation and normal progression through mitosis. Whether FBXW7 are coordinately regulated during not known. Here, we show negative regulator for B. Ectopic expression can suppress the Accordingly, deficiency leads to elevation. Mechanistic studies all isoforms regulators ubiquitination-mediated protein degradation. interacts with R465 R505 residues WD 40 domain FBXW7. Significantly, inverse correlation between elevation translated into deregulation FBWX7 mitigates B-mediated cell growth deregulation. In addition, reduces percentage multinucleated cells caused overexpression. These data suggest B, loss or mutation as seen many types cancer could lead abnormal result deregulated mitosis, which accelerates growth.